March 2023 – Astaxanthin and its Nano Formulations
What is Astaxanthin, how is it beneficial for our body, and what can we expect from combining this substance with nano formulations? These were the questions we sought to answer together with our scientific partners from the University of Chemistry and Technology, Prague (UCT Prague) and the National Institute of Mental Health, Czech Republic (NIMH CZ).
Astaxanthin, also known as the "king of carotenoids," is a powerful red-colored antioxidant. It is a natural substance produced by algae, specifically the species Haematococcus pluvialis, from which Astaxanthin is extracted. Scientific studies suggest that it may be beneficial in treating skin problems and also as a preventive measure for cardiovascular diseases.
In nature, Astaxanthin is found in marine organisms and is responsible for giving salmon, lobsters, crabs, and shrimp their characteristic red-orange color. Astaxanthin is 550 times more effective than catechins in green tea and more effective than vitamin E. It never converts into a pro-oxidant, meaning it does not cause destructive oxidation in the body. This gives it significant health benefits and enhances overall performance. Approximately 80% of people taking natural Astaxanthin feel its effects within a few months.
The goal of our project was to utilize the therapeutic properties of Astaxanthin, considered the most powerful antioxidant – up to 6000 times stronger than vitamin C. This substance can neutralize up to 19 types of free radicals in the body, supporting the immune system and cell regeneration.
To further increase the effectiveness and bioavailability of the substance, we chose a liposomal delivery form. The active ingredient is encapsulated in liposomes with a size of up to 20 nm, where we expect up to 80% bioavailability when administered as an oral spray. Our aim is to find the optimal liposome composition so that the cost-effectiveness ratio and verified clinical efficacy provide a competitive advantage on the market. The research also includes describing the benefits of liposomal Astaxanthin formulation, its potential side effects, and interactions with other drugs.
June 2024 – Research on Cycloastragenol
Our research on Cycloastragenol attracted attention due to its potential ability to slow down the aging process of human cells. Our study focused on increasing the bioavailability and efficacy of this compound, with participation from the National Institute of Mental Health, Czech Republic (NIMH CZ) under the leadership of RNDr. Karel Valeš.
Cycloastragenol is a compound extracted from the plant Astragalus membranaceus (also known as milkvetch). An increasing body of scientific evidence suggests that it has a wide range of pharmacological effects, primarily in the area of aging. Studies focus on its anti-aging properties and other positive benefits for the body.
The use of liposomal formulations at the nanometer scale represents a new chapter in pharmaceutical drug delivery. Clinical evaluations indicate that nano forms of drugs may soon replace many current forms with difficult and low bioavailability.
Achieving these goals requires collaboration with scientific institutions such as ICRC-FN USA (International Center for Scientific Research at St. Anne’s University Hospital), the University of Chemistry and Technology, Prague (UCT Prague), and the National Institute of Mental Health, Czech Republic (NIMH CZ). Through this cooperation, we can accurately describe and understand the mechanisms by which active substances reach the body and cells, while also monitoring their possible interactions and side effects.
